Stem Cells

Stem Cell Therapies: Close to Transforming Promise into Real Patient Outcomes

Cynthia A. Challener, Ph.D.

Pharma's Almanac

In Vivo Selection

Repairing More Tissue Than You Edit: What In Vivo Selection Could Mean for Gene Therapy

David Alvaro, Ph.D.

Pharma's Almanac

Genome Engineering

Aiming for More than Single-Base Corrections: The Technologies Opening the Genome to Therapeutic Cargo

David Alvaro, Ph.D.

Pharma's Almanac

Microbiome Editing

Editing the Microbiome in Place: From Engineered Probiotics to Programmable Ecological Therapies

David Alvaro, Ph.D.

Pharma's Almanac

Pathfinder

Lipid Nanoparticles vs. Viral Vectors for Gene Delivery: Which Platform Is Better?

Pharma's Almanac

Continuous VV

The Stepwise Future of Continuous Viral Vector Manufacturing

David Alvaro, Ph.D.

Pharma's Almanac

Pathfinder

AAV vs. Lentiviral Vectors: Which Viral Vector Is Better for Gene Therapy?

Pharma's Almanac

Roundtable

How is the increasing complexity of modalities reshaping CDMO differentiation and specialization strategies?

Pharma's Almanac

HACs

Synthetic Chromosome Therapeutics: Expanding Genomic Medicine Beyond the Limits of Gene Therapy

David Alvaro, Ph.D.

Pharma's Almanac

Pathfinder

CRISPR vs. Base Editing vs. Prime Editing: Which Genome Editing Technology Is Best?

Pharma's Almanac

Pathfinder

AAV vs. Non-Viral Gene Delivery: Which Is Better for In Vivo Gene Therapy?

Pharma's Almanac

Neuro CMC

Producing Therapies for the Brain: Manufacturing and Formulation Challenges for CNS Biologics

David Alvaro, Ph.D.

Pharma's Almanac

ATMP Fill-Finish

Designing Sterile Fill-Finish Systems for the Realities of Advanced Therapies

David Alvaro, Ph.D.

Pharma's Almanac

Allogeneic

Allogeneic CAR Cell Therapies: The Rise of Off-the-Shelf Immunotherapy

Cynthia A. Challener, Ph.D.

Pharma's Almanac

Ultra-Small-Scale

When Commercial Manufacturing Serves Dozens, Not Thousands

David Alvaro, Ph.D.

Pharma's Almanac

AAV Rare Disease

Scarcity by Design: The Manufacturing Reality of AAV Gene Therapies for Rare Indications

David Alvaro, Ph.D.

Pharma's Almanac

Insect Cell System

A Look at Insect Cell Expression for Viral Vector and Virus-Like Particle Production

Cynthia A. Challener, Ph.D.

Pharma's Almanac

T Cell Manufacturing

Promise vs. Practice: Adaptive Control Systems in Cell and Gene Therapy Bioreactors

David Alvaro, Ph.D.

Pharma's Almanac

Autologous

A Release-by-Exception Model for Cell Therapy Quality Decisions

David Alvaro, Ph.D.

Pharma's Almanac

CGT Automation

Hybrid by Design: Automation Limits in Cell Therapy Manufacturing

David Alvaro, Ph.D.

Pharma's Almanac